Quad Immune Components

What is Quad Immune?

Quad Immune consists of Thymosin alpha 1, Zinc, Vitamin D and Vitamin B Complex with Vitamin C. Quad Immune’s components have been carefully selected for their clinically demonstrated immune system optimizing effects. Quad Immune supports the human immune response against viral infections, and Thymosin alpha 1 has been shown in studies to help regulate pro-inflammatory cytokine storms.

Thymosin Alpha 1

What is Thymosin alpha 1 (Tα1)?

Thymosin alpha 1 is a naturally occurring thymic polypeptide of 28 N-terminally acetylated amino acids. Wells Pharmacy Network compounds the synthetically manufactured peptide Thymosin alpha 1 (Tα1) in a sterile solution for subcutaneous injection. It is prepared in a vial at a concentration of 3mg/ml in a 5ml solution. Tα1 is a powerful modulator of immunity and inflammation as demonstrated in over 70 clinical studies, which generally report an improvement in subjects' immune response and improved recovery times to viral infections including SARS, HIV, Hepatitis B and C.

Thymosin alpha 1 exhibits a pleiotropic mechanism of therapeutic action, upregulating the innate immune response when required, and downregulating it when not needed. Tα1 acts as a multitask protein restoring immune system homeostasis and cell-mediated immune function in various pathological and physiological conditions, including viral infections.

How does Tα1 help the immune system?

Thymosin alpha 1 induces host-derived immune effectors and balances the Th1 and Th2 responses.

The effector cells improve immunomodulatory properties and augment T lymphocyte function, via:

  • modulation of interleukin-2 (IL-2)
  • stimulation of interferon-g (IFN-g) production
  • induction of T lymphocyte cells
  • induction of Natural Killer (NK) cells
  • stimulation of thymopoiesis

Studies show that Thymosin alpha 1:

  • increases major histocompatibility complex (MHC) class-1 and Toll-like receptor expression
  • downregulates terminal deoxynucleotide transferase (TdT) activity in TdT1 thymocytes
  • antagonizes activation induced (anti-CD3) and glucocorticoid-induced thymocyte apoptosis
  • stimulates Indoleamine-2,3-Dioxygenase (IDO) activity
  • increases FoxP3 IL-10 producing regulatory T cells
  • plays a role in feedback inhibition of cytokine production
  • dampens immune response to prevent a pro-inflammatory cytokine storm
Zinc

What is Zinc?

Zinc is a chemical element found in human cells. Zinc is an important nutrient required by the human body to properly develop, grow, and maintain its structure and function. The human body needs Zinc to synthesize proteins and make DNA. Zinc also helps the human immune system to fight off various bacterial and viral infections.

How does Zinc help the immune system?

Zinc (as Zinc Picolinate) has been shown to:

  • support the proliferation of immune cells
  • decrease the incidence and duration of infections
  • reduce inflammatory response
  • reduce total mortality of elderly patients by 27%
Vitamin B and Vitamin C

What is Vitamin B Complex?

Vitamin B Complex is a combination of four B vitamins: B-2 (riboflavin), B-3 (niacin), B-6 (pyridoxine), and B-12 (cobalamin). Each vitamin B is an important micronutrient with a crucial role in multiple human body systems and functions. Vitamin B Complex supports the nervous, cardiovascular, digestive, and immune systems, as well as healthy brain function, hormone production, cholesterol production, cell health, cell metabolism, red blood cell growth, muscle tone and overall energy levels.

How does Vitamin B Complex help the immune system?

Vitamin B Complex has been shown to:

  • aid the body’s ability to prevent infections
  • promote red blood cell growth
  • support cellular health
  • play a role in immune system development

What is Vitamin C?

Vitamin C (ascorbic acid or ascorbate) is a powerful antioxidant and an essential micronutrient needed by the body for tissue repair, neurotransmitter production, proper enzyme function, and immune system response.

How does Vitamin C help the immune system?

Vitamin C has been shown to:

  • regulate the cytokine storm immune response
  • promote development and maturation of T lymphocytes
  • promote development and maturation of Natural Killer (NK) cells
  • reduce oxidative stress on tissues and organs
  • inhibit systemic inflammation
Vitamin D

What is Vitamin D?

Vitamin D is a fat-soluble vitamin that promotes calcium absorption and maintains appropriate calcium concentrations to enable bone mineralization, bone growth, and bone remodeling. Vitamin D plays a role in cell growth modulation, neuromuscular system, immune system, inflammation reduction, and overall optimal health.

How does Vitamin D help the immune system?

Vitamin D has been shown to:

  • inhibit viral replication
  • decrease inflammatory response
  • reduce infectious disease severity
Quad Immune

Package Contents

  • Thymosin α1 - 1 vial (5 mL) at 3,000 mcg/mL
  • Zinc (as Zinc Picolinate) - 30 capsules (30 mg each)
  • Vitamin B-Complex with Vitamin C - 1 vial (30 mL):
    • Vitamin B2 - 2 mg/mL
    • Vitamin B3 - 20 mg/mL
    • Vitamin B6 - 2 mg/mL
    • Vitamin B12 (as Cyanocobalamin) - 300 mcg/mL
    • Vitamin C - 20 mg/mL
  • Vitamin D3 (as Cholecalciferol) - 30 capsules (2000 IU each)

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Wells Pharmacy Network

Wells Pharmacy Network is a nationwide compounding pharmacy serving prescribers and patients in the United States and Puerto Rico through a combination of superior science and service. Wells Pharmacy Network is here for you with science-based information, advice and support - dedicated to quality, service and safety.

Scientific References

King R, Tuthill C. Immune Modulation with Thymosin Alpha 1 Treatment. Vitam Horm. 2016; 102:151-78. doi: 10.1016/bs.vh. April 3, 2016. Epub May 24, 2016.

Dorr RT, Lines R, Levine N, Brooks C, Xiang L, Hruby VJ, Hadley ME. Source: College of Medicine, Pharmacology Department, University of Arizona, Tucson, USA

Silvia Bozza, Roberta Gaziano, Pierluigi Bonifazi, Teresa Zelante, Lucia Pitzurra, Claudia Montagnoli, Silvia Moretti, Roberto Castronari, Paola Sinibaldi, Guido Rasi, Enrico Garaci, Francesco Bistoni, and Luigina Romani: Thymosin a1 activates the TLR9/MyD88/IRF7-dependent murine cytomegalovirus sensing for induction of anti-viral responses in vivo

L. A. Andreeva, I. Yu. Nagaev, M. V. Mezentseva, I. M. Shapoval, R. Ya. Podchernyaeva, V. E. Shcherbenko, L. A. Potapova, L. I. Russu, F. I. Ershov, and Academician N. F. Myasoedov Antiviral: Properties of Structural Fragments of the Peptide Selank

Cynthia W. Tuthill* and Robert S. King: Thymosin Alpha 1–A Peptide Immune Modulator with a Broad Range of Clinical Applications

Emily Gwyer Findlay, Silke M. Currie, Donald J. Davidson: Cationic Host Defence Peptides: Potential as Antiviral Therapeutics

Ha-reum Leea, Sun Young Yoona, Seok Bean Songa, Yoorim Parka, Tae Sung Kimb, Seonghan Kimc, Dae Young Hurc, Hyun Keun Songc, Hyunjeong Parkd, Daeho Choa: Interleukin-18-mediated interferon-gamma secretion is regulated by thymosin beta 4 in human NK cells

Lara J. Herrero, Suan-Sin Foo, Kuo-Ching Sheng, Weiqiang Chen, Mark R. Forwood, Richard Bucala, Suresh Mahalingama: Pentosan Polysulfate: a Novel Glycosaminoglycan-Like Molecule for Effective Treatment of Alphavirus-Induced Cartilage Destruction and Inflammatory Disease

Guangyong Ma, Jun-ichirou Yasunaga, Koichi Ohshima, Tadashi Matsumoto, Masao Matsuokaa,: Pentosan Polysulfate Demonstrates Anti-human T-Cell Leukemia Virus Type 1 Activities In Vitro and In Vivo

Jonathan M. Mansbach, Kohei Hasegawa, Nadim J. Ajami, Joseph F. Petrosino, Pedro A. Piedra, Courtney N. Tierney, Janice A. Espinola, and Carlos A. Camargo: Serum LL-37 Levels Associated With Severity of Bronchiolitis and Viral Etiology

Silke M. Currie1, Emily Gwyer Findlay1, Brian J. McHugh1, Annie Mackellar, Tian Man1,2, Derek Macmillan3, Hongwei Wang1,4, Paul M. Fitch1, Jurgen Schwarze1, Donald J. Davidson: The Human Cathelicidin LL-37 Has Antiviral Activity against Respiratory Syncytial Virus

Ivy Widjaja, Chunyan Wang, Rien van Haperen, Javier Gutiérrez-Álvarez, Brenda van Dieren, Nisreen M.A. Okba, V. Stalin Raj, Wentao Li, Raul Fernandez-Delgado, Frank Grosveld, Frank J. M. van Kuppeveld, Bart L. Haagmans, Luis Enjuanes, Dubravka Drabek & Berend-Jan Bosch (2019): Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein, Emerging Microbes & Infections, 8:1, 516-530, DOI: 10.1080/22221751.2019.1597644

Hajo Haase and Lothar Rink: The immune system and the impact of zinc during aging

Martinez-Estevez NS, Alvarez-Guevara AN, Rodriguez-Martinez CE. Effects of zinc supplementation in the prevention of respiratory tract infections and diarrheal disease in Colombian children: A 12-month randomised controlled trial. Allergol Immunopathol (Madr). 2016;44(4):368‐375. doi:10.1016/j.aller. December 6, 2015. Epub May 30, 2016.

Singh M, Das RR. Zinc for the common cold. Cochrane Database Syst Rev. 2013;(6):CD001364. Published 2013 Jun 18. doi:10.1002/14651858.CD001364.pub4.

Daren L Knoell, Mark W Julian, Shengying Bao, Beth Besecker, Jennifer E Macre, George D Leikauf, Robert A DiSilvestro, and Elliott D Crouser. Zinc deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis. Crit Care Med. 2009;37(4):1380‐1388. doi:10.1097/CCM.0b013e31819cefe4.

Simin N. Meydani, Junaidah B. Barnett, Gerard E. Dallal, Basil C. Fine, Paul F. Jacques, Lynette S. Leka, and Davidson H. Hamer. Serum zinc and pneumonia in nursing home elderly [published correction appears in Am J Clin Nutr. 2008 Apr;87(4):1071]. Am J Clin Nutr. 2007;86(4):1167‐1173. doi:10.1093/ajcn/86.4.1167.

University of Melbourne: How the body uses vitamin B to recognize bacterial infection

Lubna Mahmood: The metabolic processes of folic acid and Vitamin B12 deficiency

Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients. 2016;8(2):68. Published 2016 Jan 27. doi:10.3390/nu8020068.

Axelrod AE. Role of the B vitamins in the immune response. Adv Exp Med Biol. 1981;135:93‐106. doi:10.1007/978-1-4615-9200-6_5.

Boretti A, Banik BK. Intravenous Vitamin C for reduction of cytokines storm in Acute Respiratory Distress Syndrome [published online ahead of print, 2020 Apr 21]. PharmaNutrition. 2020;12:100190. doi:10.1016/j.phanu.2020.100190.

van Gorkom GNY, Klein Wolterink RGJ, Van Elssen CHMJ, Wieten L, Germeraad WTV, Bos GMJ. Influence of Vitamin C on Lymphocytes: An Overview. Antioxidants (Basel). 2018;7(3):41. Published 2018 Mar 10. doi:10.3390/antiox7030041.

Aristo Vojdani and Mamdooh Ghoneum: In vivo effect of ascorbic acid on enhancement of human natural killer cell activity

Giuseppe Valacchi, Claudia Sticozzi, Giuseppe Belmonte, Franco Cervellati, Julien Demaude, Nannan Chen, Yevgeniy Krol, and Christian Oresajo. Vitamin C Compound Mixtures Prevent Ozone-Induced Oxidative Damage in Human Keratinocytes as Initial Assessment of Pollution Protection. PLoS One. 2015;10(8):e0131097. Published 2015 Aug 13. doi:10.1371/journal.pone.0131097.

Ellulu MS, Rahmat A, Patimah I, Khaza'ai H, Abed Y. Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial. Drug Des Devel Ther. 2015;9:3405‐3412. Published 2015 Jul 1. doi:10.2147/DDDT.S83144.

Teymoori-Rad M, Shokri F, Salimi V, Marashi SM. The interplay between vitamin D and viral infections. Rev Med Virol. 2019;29(2):e2032. doi:10.1002/rmv.2032. Epub January 6, 2019.

Yin K, Agrawal DK. Vitamin D and inflammatory diseases. J Inflamm Res. 2014;7:69‐87. Published 2014 May 29. doi:10.2147/JIR.S63898.

Alexandra Yamshchikov, Nirali Desai, Henry Blumberg, Thomas Ziegler, and Vin Tangpricha: Vitamin D for Treatment and Prevention of Infectious Diseases: A Systematic Review of Randomized Controlled Trials

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This product is not intended to diagnose, treat, cure, or prevent any disease.